Clinical features and treatment of maturity onset diabetes of the young (MODY)
نویسندگان
چکیده
Maturity onset diabetes of the young (MODY) is a heterogeneous group of disorders that result in β-cell dysfunction. It is rare, accounting for just 1%-2% of all diabetes. It is often misdiagnosed as type 1 or type 2 diabetes, as it is often difficult to distinguish MODY from these two forms. However, diagnosis allows appropriate individualized care, depending on the genetic etiology, and allows prognostication in family members. In this review, we discuss features of the common causes of MODY, as well as the treatment and diagnosis of MODY.
منابع مشابه
ABCC8-Related Maturity-Onset Diabetes of the Young (MODY12): Clinical Features and Treatment Perspective
Maturity-onset diabetes of the young (MODY) is a heterogeneous group of diseases associated with gene mutations leading to dysfunction of pancreatic β-cells. Thirteen identified MODY variants differ from each other by the clinical course and treatment requirement. Currently, MODY subtypes 1-5 are best-studied, descriptions of the other forms are sporadic. This article reports a MODY12 clinical ...
متن کاملWho should have genetic testing for maturity-onset diabetes of the young?
Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous group of monogenic disorders characterized by autosomal dominant inheritance of young-onset, non-insulin-dependent diabetes. The genes involved are important in beta cell development, function and regulation and lead to disorders in glucose sensing and insulin secretion. Heterozygous GCK mutations cause impaired glucokina...
متن کاملMaturity onset diabetes of young type 2 due to a novel de novo GKC mutation.
Maturity Onset Diabetes of Young (MODY) is a heterogeneous group of monogenic disorders that result in β-cell dysfunction, with an estimated prevalence of 1%-2% in industrialized countries. MODY generally occurs in non-obese patients with negative autoantibodies presenting with mild to moderate hyperglycemia. The clinical features of the patients are heterogeneous, depending on the different ge...
متن کاملFrequency and genetic spectrum of maturity-onset diabetes of the young (MODY) in southern New Zealand
Maturity-Onset Diabetes of the Young (MODY) is a monogenic form of diabetes, consisting of a heterogeneous group of autosomal dominant inherited disorders. Typical onset is in individuals prior to twenty five years, and presentation can mimic type 1 or 2 diabetes. Molecular genetic testing can allow precise identification of the different MODY sub-types. Making a specific diagnosis of MODY can ...
متن کاملNoninsulin-dependent diabetes in the young.
Non-insulin-dependent diabetes in the young (NIDDY) may be defined as diabetes occurring in patients less than 25 (or 30 years) of age, which does not require insulin for adequate metabolic control [1]. A special form of NIDDY is known as maturity-onset diabetes of the young (MODY) (2]. In this entity patients have the clinical features of NIDDY, but in addition the diabetes is inherited in an ...
متن کامل